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  • what makes a drug stable

    4 all u chemists out there. one of a common interview question is what makes a drug stable?

    n e answers? would it have to do with its chemical structure?
    [FONT="Impact"][SIZE="5"][COLOR="Purple"]Nenah[/COLOR][/SIZE][/FONT]

  • #2
    Stability

    Originally posted by nenah View Post
    4 all u chemists out there. one of a common interview question is what makes a drug stable?

    n e answers? would it have to do with its chemical structure?
    The chemical structure is the key

    Its all a comprimise.
    It needs to be chemically stable so that you can formulate it and for it to have a reasonable shelf life. You don't want it to be acid labile otherwise you have to buffer it or coat it that gastroresistant stuff. As well as that you don't want it to be digestable so that you have to stick to parenteral routes (injectable).

    Metabolically, you don't want a lot of first pass metabolism, unless you have had to make a pro-drug. You don't really want a lot of liver metabolism because you get drug interactions. You want a half life so that dosing is once per day. You don't want it to be to lipophilic as it will accumulate.

    However, if we suddenly found a cure for alzheimers or another debilitating condition that costs the NHS millions all the above would be of little concern as long as the stuff worked!
    47 BC : Julius Cesar : Veni Vidi Vici : I came, I saw I conquered.
    2018 AD : Modern Man : I shopped, I clicked, I collected.
    How times change.

    If you find you have read something that has upset or offended you an anyway please unread it at once.

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    • #3
      Originally posted by Pharmanaut View Post

      However, if we suddenly found a cure for alzheimers or another debilitating condition that costs the NHS millions all the above would be of little concern as long as the stuff worked!

      All you have to do then is get NICE to OK it!
      Linnear MRPharmS

      Foetal Alcohol Spectrum Disorder: The biggest cause of brain damage and 100% preventable.

      In pregnancy: 1 fag is not safe, 1 x-ray is not safe and 1 drink is not safe.



      For handy pharmacy links try
      pharmacistance.co.uk

      If you like my posts or letters in the journal try my books!
      eloquent-e-tales

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      • #4
        Nice

        Originally posted by Linnear View Post
        All you have to do then is get NICE to OK it!
        If the drug was very effective but also cheap eg 10p per day how long would it take NICE to make a decision?
        47 BC : Julius Cesar : Veni Vidi Vici : I came, I saw I conquered.
        2018 AD : Modern Man : I shopped, I clicked, I collected.
        How times change.

        If you find you have read something that has upset or offended you an anyway please unread it at once.

        Comment


        • #5
          The new ones never cost 10p though do they?


          Saying that did you see this:

          http://www.pharmj.com/Editorial/2006.../spectrum.html

          Interesting reading and something I've always said.

          Why should the NHS pay for Aspirin and Calpol. Blacklist the lot!
          Linnear MRPharmS

          Foetal Alcohol Spectrum Disorder: The biggest cause of brain damage and 100% preventable.

          In pregnancy: 1 fag is not safe, 1 x-ray is not safe and 1 drink is not safe.



          For handy pharmacy links try
          pharmacistance.co.uk

          If you like my posts or letters in the journal try my books!
          eloquent-e-tales

          Comment


          • #6
            Everybody Knows

            Originally posted by Linnear View Post
            The new ones never cost 10p though do they?


            Saying that did you see this:

            http://www.pharmj.com/Editorial/2006.../spectrum.html

            Interesting reading and something I've always said.

            Why should the NHS pay for Aspirin and Calpol. Blacklist the lot!
            Agreed, everybody knows that the NHS drugs budget is the way it is because the "greedy pharmacists are dispensing too many prescriptions". (A quote [perhaps misquoted] from a tabloid from a few years ago).

            I think there's a mystique around stuff that is OTC. It is viewed a more powerful when the patient has it prescribed and does not know that it is OTC and also does not know that it is low cost.

            The "Broad Spectrum" Article should be reprinted in the daily press.
            However, I'm very jaded about what would happen as the NHS would have to get a management consultant or two in to investigate and set savings targets; and they would have to employ some managers with accompanying support staff to look make sure that the savings targets were met.
            47 BC : Julius Cesar : Veni Vidi Vici : I came, I saw I conquered.
            2018 AD : Modern Man : I shopped, I clicked, I collected.
            How times change.

            If you find you have read something that has upset or offended you an anyway please unread it at once.

            Comment


            • #7
              Saving money

              I have long experience of companies spending thousands to save pence.

              MkKinsey were one of the companies offering to save a business money but their services were always very expensive.
              johnep

              Comment


              • #8
                Originally posted by Pharmanaut View Post

                The "Broad Spectrum" Article should be reprinted in the daily press.
                However, I'm very jaded about what would happen as the NHS would have to get a management consultant or two in to investigate and set savings targets; and they would have to employ some managers with accompanying support staff to look make sure that the savings targets were met.
                I wrote a bloody long letter to DoH pointing out wastages happening on a daily basis on FP10s. I got the stock reply of "It's up to Dr's to stop wastage and we have looked into altering exemptions but we believe yahda yahda yahda."

                In other words, "If we make people pay for stuff we'll lose votes, regardless of whether the whole NHS goes tits up or not!"

                Good here ain't it?

                Linnear MRPharmS

                Foetal Alcohol Spectrum Disorder: The biggest cause of brain damage and 100% preventable.

                In pregnancy: 1 fag is not safe, 1 x-ray is not safe and 1 drink is not safe.



                For handy pharmacy links try
                pharmacistance.co.uk

                If you like my posts or letters in the journal try my books!
                eloquent-e-tales

                Comment

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