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  • Quick Question

    In lehman's terms what does 'The effect (of drug A) tends to be enhanced by chlorination but reduced by methylation' actually mean?

  • #2
    Re: Quick Question

    In Layman's terms:

    Drug A + Cl = more potent
    Drug A + CH3 = less potent

    Cl or CH3 are either swapped with another radical in the original drug A or added. The new compound will have different physico-chemical properties (solubility,polarity..) that increase or decrease its potency.

    Now to complicate things, there're Chloromethylation reactions as well but that's beyond your query.

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    • #3
      Re: Quick Question

      Originally posted by Shwampa View Post
      In Layman's terms:

      Drug A + Cl = more potent
      Drug A + CH3 = less potent

      Cl or CH3 are either swapped with another radical in the original drug A or added. The new compound will have different physico-chemical properties (solubility,polarity..) that increase or decrease its potency.

      Now to complicate things, there're Chloromethylation reactions as well but that's beyond your query.
      Might also end up with different drug interactions, or could be toxic!
      47 BC : Julius Cesar : Veni Vidi Vici : I came, I saw I conquered.
      2018 AD : Modern Man : I shopped, I clicked, I collected.
      How times change.

      If you find you have read something that has upset or offended you an anyway please unread it at once.

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      • #4
        Re: Quick Question

        Great, that's very helpfull, thank you.

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        • #5
          Re: Quick Question

          Have noted how fluoro derivatives often more potent.
          johnep

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