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  • Melanotan

    had an enquiry about a product called melanotan - supposed to be an injectable hormone analogue which stimulates tanning. Anyone heard anything good/bad about it?
    “It's not worth doing something unless you were doing something that someone, somewhere, would much rather you weren't doing.”

    Terry Pratchett

  • #2
    Re: Melanotan

    Originally posted by Sir_Dispensalot View Post
    had an enquiry about a product called melanotan - supposed to be an injectable hormone analogue which stimulates tanning. Anyone heard anything good/bad about it?
    No, but it sounds bad. <g>
    47 BC : Julius Cesar : Veni Vidi Vici : I came, I saw I conquered.
    2018 AD : Modern Man : I shopped, I clicked, I collected.
    How times change.

    If you find you have read something that has upset or offended you an anyway please unread it at once.

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    • #3
      Re: Melanotan

      yea, quite recently in news, but dont think its in commercial production, maybe will search the net for it when i can be assed,
      We are the music makers, We are the dreamers of dreams and God damn we are that good

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      • #4
        Re: Melanotan

        Melanotan and Melanotan II

        Recently found this article, did some research because loads of people keep coming in asking to buy needles to inject it with. I'm not really sure where we stand on this tho because Melanotan is technically illegal, but it is presumably still better that users have clean needles
        Has anyone else had this problem?

        Comment


        • #5
          Re: Melanotan

          Melanotan.org : find info and forums for afamelanotide (formerly CUV1647), bremelanotide, and Melanotan II here.

          I bet the rush to use it is due to melanotan 2 sexual actions....again the viagra story repeats itself: we give the product for a skin condition and the poor patients get an unwanted erection.

          Comment


          • #6
            Re: Melanotan

            Originally posted by Shwampa View Post
            we give the product for a skin condition and the poor patients get an unwanted erection.
            well if we used it at least a few of us might have somewhere to balance our pens whilst we counsel a patient!
            “It's not worth doing something unless you were doing something that someone, somewhere, would much rather you weren't doing.”

            Terry Pratchett

            Comment


            • #7
              Re: Melanotan

              Originally posted by happy_bunny View Post
              Melanotan and Melanotan II

              Recently found this article, did some research because loads of people keep coming in asking to buy needles to inject it with. I'm not really sure where we stand on this tho because Melanotan is technically illegal, but it is presumably still better that users have clean needles
              Has anyone else had this problem?

              Remember to log it in your CPD!
              Even if you only cut and paste from here!

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              • #8
                Re: Melanotan

                Hi folks, my first post here but since this i my specialist subject at the moment I thought i'd better chip in.

                Before I continue, I am a drug researcher at Liverpool John Moores University. My remit centres around injecting drug use and to that end I also provide monitoring for needle exchange, both fixed site and pharmacy, as well as contributing to training across the north west.

                So, having got that out of the way...this is the deal with Melanotan; by the way...this is the brief version, I am more than happy to provide people with more information if you wish.

                Melanotan comes in two forms. Melanotan I & II. Melanotan II is the one that increases libido. The drug is an analog of alpha-melanocyte stimulating hormone which increases melanin production; the idea being to provide a sunless tan.

                The drug is injected subcutaneously, usually in the belly fat somewhere near the belly button.

                Only two companies have the licence for this drug - Clinuvel and Palatin - and it is in Phase III trials for a number of conditions (such as Polymorphous Light Eruptions). The Melanotan II version was trialed for sexual dysfunction but that has been discontinued due to the high incidence of hypertension amongst trial participants.

                +++EDIT: Please note the high incidence of hypertension is more a feature of bremalnotide, the analogue of MT-II. However a small number of trial participants in teh most recent human trials of MT-II (2008) id experience rapid and extreme rises in blood pressure. Please note also, this may or may not be an issue for people buying it over the internet...but the fact they don't REALLY know what they are putting in the syringe is a much bigger one. The comment about hypertension may have been overstated but it was appropariate with informaion available to me at the time. I do make mistakes sometimes....surprisingly.. however hypertension is and remains an issue for some people with this drug++++



                The drug people are buying from the internet, as well as some beauty salons/hairdressers/randoms in pubs..is originally sold as a "research peptide, not for human use". This is povided by other companies, including some in China - which given their recent record leaves me rather worried!

                It is an unlicenced medicine and is illegal to sell but not to possess.

                As regards the provision of injecting equipment for it - I would say yes, do it PLEASE!!!

                The kits being provided, especially over the internet, are frightening to say the least. Inkjet printed labels stuck on supposedly sterile vials - or in the case of the ready mixed stuff we bought - small vials with caps that had clearly been prised off before the stuff was mixed. The kits have one or two syringes in them, unwrapped. Given the need for daily injections for 10 days or more to start with - providing one needle is scary to say the least.

                We've had reports of groups of young girls sharing one syringe between them for two weeks. I think you'll agree there is a significant problem there.

                For those providing syringe exchange; please do provide suitable kit (insulin needles) and advice on proper injection. In particular the inherent dangers in the following:

                Re-using or sharing injecting equipment
                Subcutaneous injection (much higher risk of bacterial infection...even if they do think they're "clean")
                The difference between "clean" (i shower regularly) and "clinically clean" (i swabbed the injecting site first)

                It could also be worth pointing out that, despite what it says on internet sites and forums - the drug has NOT been found safe for general human use, it is NOT licenced as a cometic..and won't be - and that the kits are not put together by people who really understand sterile procedure or human physiology. So the risks are actually quite high.

                I hope this is of some use to you - feel free to contant me if you want any more information about it, or round needle exchange generally for that matter. Always happy to natter
                Last edited by martin0642; 5, February 2009, 09:08 AM. Reason: clarifying my position

                Comment


                • #9
                  Re: Melanotan

                  I am an Environmental Health Officer who has been looking into the regulation of this product for some months now. I am having difficulty establishing whether this is a cosmetic or medical product. The MHRA say the product does not hold a licence as a medicine and cannot be distributed commercially within the UK. Has any of your research covered the regulation of this product?

                  Comment


                  • #10
                    Re: Melanotan

                    EHO, it's an analog of a naturally occurring hormone therefore it's a drug and is subject to regulation by the MRHA - it's not from a natural source so cannot be classified as a herbal product either.
                    Martin is quite right to say that it is an unlicenced medicine and is illegal to sell but not to possess. If you know of any salons or shops selling it then it's time to pay them as visit as they are breaking the medicines act act the very least.
                    As martin's extremely good reply outlines if it's coming into the UK with crap injection equipment / poor sterile procedures used when packing then it's only a matter of time until someone dies using it.
                    If you get the opportunity to take down dodgy retailers selling the unregulated crap then stomp on them with the full force of your right boot, or failing that the right boot of the law.

                    If your regs can't get them could trading standards?

                    This however isn't to say that if it does eventually pass all the legal hurdles and obtains a uk marketing authorisation that perfectly safe kits will become available (we could even see it going the way of these 'botox parties')
                    “It's not worth doing something unless you were doing something that someone, somewhere, would much rather you weren't doing.”

                    Terry Pratchett

                    Comment


                    • #11
                      Re: Melanotan

                      It's being sold as an unscheduled research chem labeled as "not for human consumption" therefore perfectly legal to sell online. At least in the US that is, I don't know about the UK.

                      Personally I think it has an incredible amount of potential, just look at the rates of skin cancer from sun exposure. Problem is, that if it's causing libido boosts and hypertension then obviously this stuff isn't very selective for what it's marketed for.

                      Comment


                      • #12
                        Re: Melanotan

                        Thanks for your reply but unfortunately, as I've stated, the MHRA do not class this product as a medicine as yet, making it difficult for us to regulate. Equally, trading standards may only become involved if the product is definately classed as a cosmetic. Sadly we can only work within out legal parameters.

                        Comment


                        • #13
                          Re: Melanotan

                          could they be done under the law for selling 'drugs paraphanalia' - ie supplying injection equipment which has not passed the correct guidelines or standards for sale?
                          “It's not worth doing something unless you were doing something that someone, somewhere, would much rather you weren't doing.”

                          Terry Pratchett

                          Comment


                          • #14
                            Re: Melanotan

                            Originally posted by martin0642 View Post
                            Hi folks, my first post here but since this i my specialist subject at the moment I thought i'd better chip in.

                            Before I continue, I am a drug researcher at Liverpool John Moores University. My remit centres around injecting drug use and to that end I also provide monitoring for needle exchange, both fixed site and pharmacy, as well as contributing to training across the north west.

                            So, having got that out of the way...this is the deal with Melanotan; by the way...this is the brief version, I am more than happy to provide people with more information if you wish.

                            Melanotan comes in two forms. Melanotan I & II. Melanotan II is the one that increases libido. The drug is an analog of alpha-melanocyte stimulating hormone which increases melanin production; the idea being to provide a sunless tan.

                            The drug is injected subcutaneously, usually in the belly fat somewhere near the belly button.

                            Only two companies have the licence for this drug - Clinuvel and Palatin - and it is in Phase III trials for a number of conditions (such as Polymorphous Light Eruptions). The Melanotan II version was trialed for sexual dysfunction but that has been discontinued due to the high incidence of hypertension amongst trial participants.

                            The drug people are buying from the internet, as well as some beauty salons/hairdressers/randoms in pubs..is originally sold as a "research peptide, not for human use". This is povided by other companies, including some in China - which given their recent record leaves me rather worried!

                            It is an unlicenced medicine and is illegal to sell but not to possess.

                            As regards the provision of injecting equipment for it - I would say yes, do it PLEASE!!!

                            The kits being provided, especially over the internet, are frightening to say the least. Inkjet printed labels stuck on supposedly sterile vials - or in the case of the ready mixed stuff we bought - small vials with caps that had clearly been prised off before the stuff was mixed. The kits have one or two syringes in them, unwrapped. Given the need for daily injections for 10 days or more to start with - providing one needle is scary to say the least.

                            We've had reports of groups of young girls sharing one syringe between them for two weeks. I think you'll agree there is a significant problem there.

                            For those providing syringe exchange; please do provide suitable kit (insulin needles) and advice on proper injection. In particular the inherent dangers in the following:

                            Re-using or sharing injecting equipment
                            Subcutaneous injection (much higher risk of bacterial infection...even if they do think they're "clean")
                            The difference between "clean" (i shower regularly) and "clinically clean" (i swabbed the injecting site first)

                            It could also be worth pointing out that, despite what it says on internet sites and forums - the drug has NOT been found safe for general human use, it is NOT licenced as a cometic..and won't be - and that the kits are not put together by people who really understand sterile procedure or human physiology. So the risks are actually quite high.

                            I hope this is of some use to you - feel free to contant me if you want any more information about it, or round needle exchange generally for that matter. Always happy to natter

                            Hi, I am a student Environmental Health officer, and lately have heard of a few people using Melanotan (not fully sure whether I or II is used). I have been in contact with a number of other officers who are not even aware of this injection. I have been collecting information on the products, and if it would be possible could you please send me some information that you have been working on. This could be a potentially hot topic for me and a possible dissertation topic.
                            My e-mail address seems to be blocking e-mails from the website, so if i send you my work's e-mail could you possibly send some information through to me please?

                            Thank You

                            Comment


                            • #15
                              Re: Melanotan

                              Seems this stuff is turning into quite the hot product. The MHRA are on the cusp of making an announcement about it, sometime within the next week or so I think.

                              We have serious concerns about the supposed sterility of the stuff being sold in the kits, but i'll come back to that one when I have better information to pass on. Suffice to say - sterile they were not!!

                              As regard the possibility of it going like botox parties - I sincerely doubt it. Neither the MHRA or the FDA seems interested in this stuff going down a cosmetic route - several of the more recent trials have been discontinued due to side effect and most importantly....people using it in conjunction with sunbeds, which completely negates the point of the stuff, are now starting to report symptoms that have not been seen in trials. Like the eruption of moles all over the body, including several pre-cancerous. Only one case of that, that I know of, and of course it could have been that one in a million. However.... so little is known about the effects this stuff has...and with the massive rise in young people injecting, re-using and sharing equipment etc etc... frankly, even if it DOES have potential, people have shot themselves in the foot. By jumping all over it and exposing themselves to such high risks to start with they have probably killed off any chance of it being available legally and safely.

                              We'll see eh?

                              ENV SP - i'll get back to you when i'm back in the office, which will hopefully be tomorrow (off sick at the moment!)

                              M

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