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  • AutoInducers

    Are there other drugs, which like carbamazepine are autoinducers?
    Im nearing the end of my pre reg year and only found out about this property of carbamazepine YESTERDAY!! Please educate me!!!!!
    Regards, L X

  • #2
    Re: AutoInducers

    What about ethanol?

    Originally posted by lmcder View Post
    Are there other drugs, which like carbamazepine are autoinducers?
    Im nearing the end of my pre reg year and only found out about this property of carbamazepine YESTERDAY!! Please educate me!!!!!
    Regards, L X
    Real stupidity beats artificial intelligence every time.
    (T. Pratchett)

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    • #3
      Re: AutoInducers

      What about smoke?

      Originally posted by paul2008 View Post
      What about ethanol?

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      • #4
        Re: AutoInducers

        What about smoke?

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        • #5
          Re: AutoInducers

          Barbiturates - ive been informed are another one!!

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          • #6
            Re: AutoInducers

            Originally posted by lmcder View Post
            Barbiturates - ive been informed are another one!!
            Rifampicin might be as well.
            47 BC : Julius Cesar : Veni Vidi Vici : I came, I saw I conquered.
            2018 AD : Modern Man : I shopped, I clicked, I collected.
            How times change.

            If you find you have read something that has upset or offended you an anyway please unread it at once.

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            • #7
              Re: AutoInducers

              Originally posted by lmcder View Post
              Are there other drugs, which like carbamazepine are autoinducers?
              Im nearing the end of my pre reg year and only found out about this property of carbamazepine YESTERDAY!! Please educate me!!!!!
              Regards, L X
              I remember hearing about this in Uni pharmacology/kinetics lectures. Here's the relevant bits cut and pasted from my old notes.

              • Drugs that stimulate hepatic microsomal enzyme production may stimulate their own metabolism
              • This process is known as ‘self-induction’ or ‘auto-induction’
              • In some cases, this process explains the phenomenon of tolerance
              • Examples of drugs that induce their own hepatic metabolism include:
              o Carbamazepine (Anticonvulsant)
              o Diazepam (Benzodiazepine)
              o Glutethimide (Hypnotic sedative)
              o Glyceryl trinitrate (Vasodilator)
              o Meprobamate (Anxiolytic)
              o Phenobarbital (Barbiturate)
              o Phenylbutazone (NSAID)
              o Phenytoin (Antiepileptic)
              o Tolbutamide (Sulphonylurea)

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              • #8
                Re: AutoInducers

                Thankyou very much, thats brilliant, X

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                • #9
                  Re: AutoInducers

                  Originally posted by pharmatron View Post
                  Here's the relevant bits cut and pasted from my old notes.
                  How old? Some of these drugs are long gone

                  Jeff

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                  • #10
                    Re: AutoInducers

                    Originally posted by Jeff View Post
                    How old? Some of these drugs are long gone

                    Jeff
                    I know...and the notes are only a few years old. I suspect they were out of date when they were issued to us. Some of the older lecturers are very good at delivering the science and getting students to understand the principles, but their notes aren't always up to date with current clinical practice.

                    However, there are a few useful examples and the pharmacokinetic principles remain the same.

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