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  • Digoxin

    how many days should i consider 125mcg PO QD to reach its steady state?

  • #2
    Re: Digoxin

    Originally posted by jeffradd View Post
    how many days should i consider 125mcg PO QD to reach its steady state?
    Biological half-life - Wikipedia, the free encyclopedia
    "So, for example, digoxin has a half-life (or t½) of 24-36 hours; this means that a change in the dose will take the best part of a week to take full effect"

    However I can't see a reason for taking digoxin 125mcg QD rather than 500mcg as a daily dose - but that's just intuition - I haven't gone through the maths.

    Is the intention to reach a steady state or to establish a clinical effective more quickly and then reduce the dose?

    Jeff

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    • #3
      Re: Digoxin

      Jeff thanks. to reach steady state. how many days?

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      • #4
        Re: Digoxin

        Sounds like high dose to me. Too many deaths in past to make me complacent.
        Latest was 250mcg instead of 62.5mcg in a MDS tray.
        johnep

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        • #5
          Re: Digoxin

          im not a professional. its just a question.

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          • #6
            Re: Digoxin

            so about one week to reach steady state???

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            • #7
              Re: Digoxin

              Yep - a longer quote from the wiki link I gave in my first reply.

              "In clinical practice, this means that it takes just over 4.7 times the half-life for a drug's serum concentration to reach steady state after regular dosing is started, stopped, or the dose changed. So, for example, digoxin has a half-life (or t½) of 24-36 hours; this means that a change in the dose will take the best part of a week to take full effect."

              So 4.7 x 1 (day if 24 hour half life) = 4.7 days
              or 4.7 x 1.5 days (if a 36 hour half life) = 7 days

              Jeff

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              • #8
                Re: Digoxin

                thanks for your help and a great explanation

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                • #9
                  Re: Digoxin

                  Originally posted by Jeff View Post
                  Biological half-life - Wikipedia, the free encyclopedia
                  "So, for example, digoxin has a half-life (or t½) of 24-36 hours; this means that a change in the dose will take the best part of a week to take full effect"

                  However I can't see a reason for taking digoxin 125mcg QD rather than 500mcg as a daily dose - but that's just intuition - I haven't gone through the maths.

                  Is the intention to reach a steady state or to establish a clinical effective more quickly and then reduce the dose?

                  Jeff
                  Is QD the same as OD as written here in UK?
                  47 BC : Julius Cesar : Veni Vidi Vici : I came, I saw I conquered.
                  2018 AD : Modern Man : I shopped, I clicked, I collected.
                  How times change.

                  If you find you have read something that has upset or offended you an anyway please unread it at once.

                  Comment


                  • #10
                    Re: Digoxin

                    QD seems to be once a day in the US.
                    Glad we use OD instead in the UK it could be taken for QDS.

                    http://www.ismp.org/Tools/errorproneabbreviations.pdf
                    47 BC : Julius Cesar : Veni Vidi Vici : I came, I saw I conquered.
                    2018 AD : Modern Man : I shopped, I clicked, I collected.
                    How times change.

                    If you find you have read something that has upset or offended you an anyway please unread it at once.

                    Comment

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