how many days should i consider 125mcg PO QD to reach its steady state?
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Digoxin
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Re: Digoxin
Originally posted by jeffradd View Posthow many days should i consider 125mcg PO QD to reach its steady state?
"So, for example, digoxin has a half-life (or t½) of 24-36 hours; this means that a change in the dose will take the best part of a week to take full effect"
However I can't see a reason for taking digoxin 125mcg QD rather than 500mcg as a daily dose - but that's just intuition - I haven't gone through the maths.
Is the intention to reach a steady state or to establish a clinical effective more quickly and then reduce the dose?
Jeff
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Re: Digoxin
Yep - a longer quote from the wiki link I gave in my first reply.
"In clinical practice, this means that it takes just over 4.7 times the half-life for a drug's serum concentration to reach steady state after regular dosing is started, stopped, or the dose changed. So, for example, digoxin has a half-life (or t½) of 24-36 hours; this means that a change in the dose will take the best part of a week to take full effect."
So 4.7 x 1 (day if 24 hour half life) = 4.7 days
or 4.7 x 1.5 days (if a 36 hour half life) = 7 days
Jeff
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Re: Digoxin
Originally posted by Jeff View PostBiological half-life - Wikipedia, the free encyclopedia
"So, for example, digoxin has a half-life (or t½) of 24-36 hours; this means that a change in the dose will take the best part of a week to take full effect"
However I can't see a reason for taking digoxin 125mcg QD rather than 500mcg as a daily dose - but that's just intuition - I haven't gone through the maths.
Is the intention to reach a steady state or to establish a clinical effective more quickly and then reduce the dose?
Jeff47 BC : Julius Cesar : Veni Vidi Vici : I came, I saw I conquered.
2018 AD : Modern Man : I shopped, I clicked, I collected.
How times change.
If you find you have read something that has upset or offended you an anyway please unread it at once.
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Re: Digoxin
QD seems to be once a day in the US.
Glad we use OD instead in the UK it could be taken for QDS.
http://www.ismp.org/Tools/errorproneabbreviations.pdf47 BC : Julius Cesar : Veni Vidi Vici : I came, I saw I conquered.
2018 AD : Modern Man : I shopped, I clicked, I collected.
How times change.
If you find you have read something that has upset or offended you an anyway please unread it at once.
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