Announcement

Collapse
No announcement yet.

Aminophylline Calculations

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Aminophylline Calculations

    Does anyone remember how to do pharmacokinetic calculations, any help would be much appreciated. Thank you guys!

    'Dr has started pt on Aminophylline SR 250mg bd, but asks you to what dose the pt is likely to require over long term, given her low body weight to achieve the therapeutic levels. using pharmacokinetics formulae, calculate a practical maintenance dose of medication to achieve therapeutic levels'


    Determining maintenance dose:

    Rate in=SxFxdose= CL x average Cpss
    T

    pt weigh: 53kg, smoker!

    Therapeutic range = 10-20 mg/L Vd = 0.48 L/kg,

    CI = 0.04 L/hr/kg.
    For patients with:
    CHF multiply CI x 0.4,
    Cirrhosis CI x 0.5,
    Severe respiratory impairment (FEV1 <1 litre) CI x 0.8, Smoking CI x 1.6

    Salt factor for aminophylline = 0.8

  • #2
    Have you googled?
    johnep

    Comment

    Working...
    X