enzyme induction?

[zeebee79]

Hi Is this for mod 7?
Hope this helps without getting confusing!!

a) Enzyme Inhibition and Enzyme Induction
Certain enzymes within the liver (cytochrome P450 (CYP) system) are responsible for converting drugs from active to inactive substances.
Some drugs may inhibit these enzymes from converting other drugs taken at the same time causing them to remain active within the body for too long. This can cause high levels of drug within the body which in turn can lead to adverse reactions and be harmful.
Some drugs can induce these enzymes, that is causing other drugs to metabolise (be converted) too quickly to the inactive substance and so not having a chance to take effect within the body.
Enzyme induction
Phenytoin given with an oral contraceptive can cause the P450 Enzymes in the liver to metabolise the contraceptive too quickly making it ineffective.
Enzyme inhibition
Metronidazole can inhibit the P450 Enzymes in the liver. If metronidazole is given with Warfarin it can reduce the rate at which it is metabolised. This in turn can enhance the effects of Warfarin within the body.

[rachel200202]

thanks guys you have all been very helpful. i now understand the basics!!

[Sophie30]

hey guys im stuck on a question in module 8, i have no help from my pharmacist...
question is Give one example of a drug interaction resulting from enzyme inhibition and enzyme induction... your help will be appreciated..

[Sophie30]

thanks ive got my answer

[Rebyoo]

Hi Is this for mod 7?
Hope this helps without getting confusing!!

a) Enzyme Inhibition and Enzyme Induction
Certain enzymes within the liver (cytochrome P450 (CYP) system) are responsible for converting drugs from active to inactive substances.
Some drugs may inhibit these enzymes from converting other drugs taken at the same time causing them to remain active within the body for too long. This can cause high levels of drug within the body which in turn can lead to adverse reactions and be harmful.
Some drugs can induce these enzymes, that is causing other drugs to metabolise (be converted) too quickly to the inactive substance and so not having a chance to take effect within the body.
Enzyme induction
Phenytoin given with an oral contraceptive can cause the P450 Enzymes in the liver to metabolise the contraceptive too quickly making it ineffective.
Enzyme inhibition
Metronidazole can inhibit the P450 Enzymes in the liver. If metronidazole is given with Warfarin it can reduce the rate at which it is metabolised. This in turn can enhance the effects of Warfarin within the body.

I found this amazingly helpful, thank you so much! The textbooks are so waffley, they spread all this information out with chatty sentences like "you might that blah, blah, blah", i wish they would stop telling me what i might think and tell me what i need to know. Thank you posting this!

[craftycaz50]

I have also found this very helpful. Thank you