Why so much sodium in Effervescent Solpadol?

[jack3]

Hi all,

I hope this the right section to post this question, my appologies if not.

Could anyone tell me Effervescent Sopadol contains do much sodium? I am an nurse and this is a question which has spurred some debate on the ward recently.

Thanks

[johnep]

Most effervescent tablets use reaction between citric acid and sodium bicarbonate to generate the carbon dioxide which gives the fizz.
The alternative is to use the potassium salt, but this is expensive.
Gaviscon advance is example of a formulation change from sodium to potassium salt.
Medical authorities are trying to reduce the use of soluble preparations because of the sodium content.
When working with a Tanzanian company on formulation of a milk powder, I suggested use of demineralised whey instead of milk powder as a means of reducing the sodium level.
johnep

[El-loco]

Also paracetamol is not soluble in water but is it soluble in a solution of sodium citrate so you need enough sodium citrate generated by the reaction johnep describes, and hence sodium.

The alternative would be to suspend the paracetamol (which makes it tasteless), as in Calpol for instance using carbapol, in a small volume of liquid and although the codeine phosphate would still dissolve and be bitter the taste could be masked. The volume of a standard dose of 60mg codeine and 1000mg paracetamol would then be 20ml and no sodium.

Of course if I had any sense I'd set about marketing such a product and make my fortune.

[johnep]

Suspect no adult liquid formulation because of suicide risk.
johnep

[jack3]

That's a great explanation, thanks so much. I can finally put this debate to rest at work.

Thanks again!