Binder requirements in High shear granulator Vs Low shear granulator (eg, fluid-bed)

[sharifhs]

As quoted in ‘Encyclopedia of Pharmaceutical Technology’ binder requirement is less in low shear or fluid-bed granulator than that of high shear granulator:

"Compared to high shear granulation, low shear or fluid bed process requires less fluid binder, not only resulting in a shorter drying time, but also in a less cohesive material" (Levin M, 2002).

As quoted in ‘Generic Drug Product Development Solid Oral Dosage Forms’ binder requirement is less in high shear granulator than that of other granulators:

"High shear granulation offers several advantages, including densification of low bulk density materials, lower binder requirement, control over porosity of granules, and easy cleaning" (Ahmed SU, 2005).

Can anybody help me actually which granulator require less binder solution?


REFERENCES:

Ahmed SU, Naini V and Wadgaonkar D (2005). In: Shargel L and Kanfer I (Editor). Generic Drug Product Development Solid Oral Dosage Forms. Marcel Dekker, New York. pp 109.

Levin M (2002). Wet Granulation: End-Point Determination and Scale-Up. In: Swarbrick J, and Boylan JC (Editors). Encyclopedia of Pharmaceutical Technology, 2nd Ed. Marcel Dekker, New York. pp 4078.

[Diddums]

I dont know the answer to this however if you are formulating a medicinal product this this is something that you should evaluate and document in the pharmaceutical development section of your dossier