Hey, I was just wondering if there was such a thing as controlled-release Diazepam in the UK?
Thanks in advance for any replies.
OJ
First Time Poster
Controlled-Release Diazepam
Hey, I was just wondering if there was such a thing as controlled-release Diazepam in the UK?
Thanks in advance for any replies.
OJ
Keep it surreal
No such thing in UK - cannot imagine such a produce would exist anywhere. Diazepam itself has a long half life and active metabolites.
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Newly registered in 1981
...Most of which have been marketed as new drugs at sometime in the UK.Originally Posted by Nik
Where am I?; In the Pharmacy.
Who are you?; The new Number 2.
Who is number 1?; You are number 6.
What do you want?;..................
Tai Chi Enhanced Member
What Nik is saying, is that Diazepam itself could be considered as if it were modified release.
....just my opinion
Keep it surreal
Don't you mean prolonged ?
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Tai Chi Enhanced Member
No.
THIS is prolonged
....just my opinion
Frequent Poster
A benzodiazepine with a longer duration of action could potentially be used instead of diazepam.
Keep it surreal
Hard to think of any other available drugs with a longer duration of action than diazepam.
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Registered Pharmacist
?nitrazepam...known for its hangover effect in the morning....half life of 24-30hours, whihc on looking is much shorter than diazepam
"Diazepam" has a biphasic half-life with an initial rapid distribution phase and a prolonged terminal elimination phase of 1 or 2 days; its action is further prolonged by the even longer half-life of 2 to 5 days of its principal active metabolite, desmethyldiazepam" so why the need for multiple daily dosing of diazepam??
Frequent Poster
Diazepam has a long half life but it's duration of action is only a few hours because it is rapidly distributed throughout the body so the plasma concentration drops below the minimum effective level long before a single half life, hence the need for multiple doses of diazepam per day. Only if someone has been taking diazepam for a prolonged period of time does the half life reflect the duration of action as the drug accumulates to significant levels.
Other benzodiazepines with a very long half life include flurazepam and chlordiazepoxide, however I'm not sure of their exact duration of action.
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