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About LinkBacksAre there other drugs, which like carbamazepine are autoinducers?
Im nearing the end of my pre reg year and only found out about this property of carbamazepine YESTERDAY!! Please educate me!!!!!
Regards, L X
Active Member
Are there other drugs, which like carbamazepine are autoinducers?
Im nearing the end of my pre reg year and only found out about this property of carbamazepine YESTERDAY!! Please educate me!!!!!
Regards, L X
Registered Pharmacist
What about ethanol?
Originally Posted by lmcder
Real stupidity beats artificial intelligence every time.
(T. Pratchett)
Apothecary
What about smoke?
Apothecary
What about smoke?
Active Member
Barbiturates - ive been informed are another one!!
Newly registered in 1981
Rifampicin might be as well.
Where am I?; In the Pharmacy.
Who are you?; The new Number 2.
Who is number 1?; You are number 6.
What do you want?;..................
Frequent Poster
I remember hearing about this in Uni pharmacology/kinetics lectures. Here's the relevant bits cut and pasted from my old notes.
• Drugs that stimulate hepatic microsomal enzyme production may stimulate their own metabolism
• This process is known as ‘self-induction’ or ‘auto-induction’
• In some cases, this process explains the phenomenon of tolerance
• Examples of drugs that induce their own hepatic metabolism include:
o Carbamazepine (Anticonvulsant)
o Diazepam (Benzodiazepine)
o Glutethimide (Hypnotic sedative)
o Glyceryl trinitrate (Vasodilator)
o Meprobamate (Anxiolytic)
o Phenobarbital (Barbiturate)
o Phenylbutazone (NSAID)
o Phenytoin (Antiepileptic)
o Tolbutamide (Sulphonylurea)
Active Member
Thankyou very much, thats brilliant, X
How old? Some of these drugs are long goneHere's the relevant bits cut and pasted from my old notes.
Jeff
Frequent Poster
I know...and the notes are only a few years old. I suspect they were out of date when they were issued to us. Some of the older lecturers are very good at delivering the science and getting students to understand the principles, but their notes aren't always up to date with current clinical practice.
However, there are a few useful examples and the pharmacokinetic principles remain the same.
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