AutoInducers

[lmcder]

Are there other drugs, which like carbamazepine are autoinducers?
Im nearing the end of my pre reg year and only found out about this property of carbamazepine YESTERDAY!! Please educate me!!!!!
Regards, L X

[paul2008]

What about ethanol?

Originally Posted by lmcder

Are there other drugs, which like carbamazepine are autoinducers?
Im nearing the end of my pre reg year and only found out about this property of carbamazepine YESTERDAY!! Please educate me!!!!!
Regards, L X

[johannes]

What about smoke?

Originally Posted by paul2008

What about ethanol?

[johannes]

What about smoke?

[lmcder]

Barbiturates - ive been informed are another one!!

[Pharmanaut]

Originally Posted by lmcder

Barbiturates - ive been informed are another one!!

Rifampicin might be as well.

[pharmatron]

Originally Posted by lmcder

Are there other drugs, which like carbamazepine are autoinducers?
Im nearing the end of my pre reg year and only found out about this property of carbamazepine YESTERDAY!! Please educate me!!!!!
Regards, L X

I remember hearing about this in Uni pharmacology/kinetics lectures. Here's the relevant bits cut and pasted from my old notes.

• Drugs that stimulate hepatic microsomal enzyme production may stimulate their own metabolism
• This process is known as ‘self-induction’ or ‘auto-induction’
• In some cases, this process explains the phenomenon of tolerance
• Examples of drugs that induce their own hepatic metabolism include:
o Carbamazepine (Anticonvulsant)
o Diazepam (Benzodiazepine)
o Glutethimide (Hypnotic sedative)
o Glyceryl trinitrate (Vasodilator)
o Meprobamate (Anxiolytic)
o Phenobarbital (Barbiturate)
o Phenylbutazone (NSAID)
o Phenytoin (Antiepileptic)
o Tolbutamide (Sulphonylurea)

[lmcder]

Thankyou very much, thats brilliant, X

[Jeff]

Originally Posted by pharmatron

Here's the relevant bits cut and pasted from my old notes.

How old? Some of these drugs are long gone

Jeff

[pharmatron]

Originally Posted by Jeff

How old? Some of these drugs are long gone

Jeff

I know...and the notes are only a few years old. I suspect they were out of date when they were issued to us. Some of the older lecturers are very good at delivering the science and getting students to understand the principles, but their notes aren't always up to date with current clinical practice.

However, there are a few useful examples and the pharmacokinetic principles remain the same.