Tetracyclin - anti inflamatory effect?

[navid_o]

has tetracycline local anti inflamtory effect? why it`s used to treat aphtus? by which mechanisem?
how about doxicyclin?

[Anonymous]

Originally Posted by navid_o

has tetracycline local anti inflamtory effect? why it`s used to treat aphtus? by which mechanisem?
how about doxicyclin?

I wonder too!!!!!!

[admin]

Hi

I meant to post to this s few days ago and forgot.
Sorry!

Tetracyclines are useful in rheumatoid arthritis by inhibiting the expression of nitric oxide. Minocycline too is a powerful immunomodulant which can subdue rheumatoid arthritis. Tetracycline and doxycycline may also act as anti-inflammatories by modulation of nitric oxide synthesis. Studies also suggest that the clinical effectiveness of doxycycline in the treatment of acne inflammation is due partly to its antioxidant effect on neutrophils.

The antibiotics act at the ribosomal level where they interfere with the protein synthesis of susceptible bacteria. They also have non antibiotic properties, which are not well understood. These nonantibioitc properties include:

Anti-inflammatory effects
Inhibition of metalloproteinases (enzymes that inhibit collagen and gelatin production)
Reduce new blood vessel formation (angiogenesis)
Reduce programmed cell death (apoptosis)

I Hope this is useful.