Interactions!

[Proteuspal]

Hi all
Just a quick question. Can someone give me a couple of good examples of 'drug-patient' and 'drug-disease' interactions? I really appreciate your help with this!
Kind regards
Proteuspal

[naf123]

It is my pleasure to help you with your homework.

Drug-patient - avoiding medicines in patients who do not have specific enzymes to metabolize the medicine e.g I remember reading somewhere that some people lack the CYP2D6 enzyme in the liver - therefore these people cannot take drugs that require those enzymes to metabolize the drug especially Codeine!


drug-disease - e.g avoid some medicines in patients with liver problems or kidney problems - is it a good idea to give paracetamol to a patient with severe liver failure?

[Nik]

Drug-patient - avoiding medicines in patients who do not have specific enzymes to metabolize the medicine e.g I remember reading somewhere that some people lack the CYP2D6 enzyme in the liver - therefore these people cannot take drugs that require those enzymes to metabolize the drug especially Codeine!

Not necessarily a lack of the enzyme, more the fact that some people are "poor metabolisers" and thus unable to convert to morphine.

[Nik]

Difficult to say avoid paracetamol in liver disease - would prefer over NSAID's (fluid retention - ascites, bleeding risk in the context of raised INR, reduced GFR) and opioids (encephalopathy risk from sedation and constipation). However could add weak opioid to paracetamol if needed.