Gentamicin would?

[jeffradd]

pharmacokinetic changes include:

gentamicin elimination (increase or decrease?), gentimicin volume of distribution willl (decrease or increase?)

thanks,
Jeff
if you want to give me a source i will go find it as well

[ferretmanabu]

Whats the question?

[jeffradd]

sorry the gustion is if one was to take this drug what would happen?

[ferretmanabu]

you might not have an infection any more.

[johnep]

I understand gentamycin is toxic and mainly used topically. rather like neomycin.
johnep

[jeffradd]

sorry my fault. please pick what would happen..increase or decrease.

pharmacokinetic changes after consumed include:

gentamicin elimination (increase or decrease?), gentimicin volume of distribution willl (decrease or increase?)

[Pharmanaut]

Originally Posted by jeffradd

pharmacokinetic changes include:

gentamicin elimination (increase or decrease?), gentimicin volume of distribution willl (decrease or increase?)

thanks,
Jeff
if you want to give me a source i will go find it as well

Elimination is mostly by kidney filtration, so any drug slowing that down will decrease elimination and extend the half life, as would poor kidney function.

Gentamicin, along with the rest of the aminoglycosides have known toxicity potential and are usually not the first choice. (neurotoxicity and ototoxicity)

The scientifically curious can have a look at the UK-SPC available at...
The electronic Medicines Compendium

This might also help.
Pharmacodynamics of Gentamicin

Google works for me - every time.

[jeffradd]

So Pharmanaut,

then from your post. you are saying

the above scenario would occur with a woman with chronic renal insafficiency with edema. after taking the drug we would expect....


as gentamicin elimination ( decreases?), gentimicin volume of distribution willl (increases?)

right???

[johnep]

What on earth do you want to know for. Gentamycin would be way down on anyones list of antibiotics. Not even sure if available for injection or oral use.
johnep

[jeffradd]

oh,,funny..dont worry im a student doing some research. this is not a functional question. i should have said that. i am not a pharmacist nor am i in pharm school nor do i plan on taking the drug or reomending it to anyone.