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Thread: H2 receptor antagonists and chemo

  1. 30th, March 2011, 09:50 AM #1
    grumpy jeff
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    H2 receptor antagonists and chemo

    Trying to find out the pharmacological reasoning behind giving ranitidine (or equivalent) as a pre-med before paclitaxel. H2 receptor antagonists work on the parietal cells in the stomach, yet paclitaxel does not exhibit common side effects in that area. Rarely, patients might get oesophagitis...
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  2. 30th, March 2011, 10:54 AM #2
    grumpy jeff
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    Re: H2 receptor antagonists and chemo

    Ok, think it's something to do with vasodilation - please confirm?
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  3. 30th, March 2011, 11:58 AM #3
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    Re: H2 receptor antagonists and chemo

    BNF mentions it along with an antihistamine (H1) and corticosteroid to prevent hypersensitivity reactions, but apart from providing extra anthistamine cover can't find any other reason
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