View Single Post
  #6 (permalink)  
Old 23rd, January 2008, 12:38 PM
mr_colt mr_colt is offline
Loyal Member
 
Join Date: Dec 2006
Posts: 63
Default Re: Cytochrome P450 2D6 (CYP2D6) testing

Thanks for the response,

I managed to bet onto Butrans after months of fighting for the medics to acknowledge that my pain is organic and not neuropathic. All the usual drugs like NSAID's, Trcyclics etc were tried with no effect.

Opioids are the only thing that have ever worked; but codeine, tramadol and DHC were barely effective on the pain. Buprenorphine has done the world of good in turning me from being almost bed-bound to housebound without door-to-door transport I suspose:

5mcg/hr is just not enough for any quality of life though, as I have mentioned in other posts. I have had to move counties to get close enough to an consultant who will script higher doses for someone my age (19) who isn't terminal.

So far it is looking like a trial increase to 10mcg/hr with Temgesic 200mcg sublinguals for breakthrough pain: From a pharm perspective is this a good combo to try? We were also thinking about oramorph for breakthrough but it only has a half-life of 4hrs and wouldnt bup's partial agonist-antagonist properties make it less effective?

mr_colt
Reply With Quote