Thread: Digoxin
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Old 2nd, October 2007, 09:04 PM
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Default Re: Digoxin

Yep - a longer quote from the wiki link I gave in my first reply.

"In clinical practice, this means that it takes just over 4.7 times the half-life for a drug's serum concentration to reach steady state after regular dosing is started, stopped, or the dose changed. So, for example, digoxin has a half-life (or t½) of 24-36 hours; this means that a change in the dose will take the best part of a week to take full effect."

So 4.7 x 1 (day if 24 hour half life) = 4.7 days
or 4.7 x 1.5 days (if a 36 hour half life) = 7 days

Jeff
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