I suspect that as with many other opiates & opioids a certain tolerance builds up over time; I have been given 10mg of morphine sulphate once, and I was sick for 48 hours because of it; but I have patients who take 200mg twice a day and seem fine, they even drive their cars, despite my warnings that their medication could seriously affect their ability to drive...!
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Ze genuine Article, present & perfect!
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