 Re: Hospital pharmacist's uniform
As to why exactly it does; I can't tell you. Pharmacoligists can't currently explain why; what they do know is that Tramadol alone seems to have a need to attach itself to the 5HT3 receptors in the spine to have a sufficient analgesic effect. Obviously 5HT3 antagonists actively prevent a lot of this from happening.
Its been the subject of a number of clinical trials in recent years; this is mainly due to the increased use due to the fall in cost as GSK maintained a prohibitively priced brand patient for 20 years. It used to be the preserve of chemotherapy patients but the use for post-operative nausea has increased significantly in recent years as generics came in. Obviously analgesics are going to be used to great extent on surgical wards, this led to the discovery about the drugs incompatibility.
After that; numerous clinical trials were run. Here's one of the better ones:
Ondansetron inhibits the analgesic effects of tramadol: a possible 5-HT(3) spinal receptor involvement in acute pain in humans.
Anesth Analg. 2002 Jun;94(6):1553-7, table of contents.
PMID: 12032025 [PubMed - indexed for MEDLINE]
mr_colt.
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