[Linnear]

Originally Posted by johnep

Someone here queried ibuprofen and methotrexate. NSAIDs plua methotrexate commonplace. BNF says 'increases toxicity' I always check pt having regular liver function tests and most have been on for years. What would you suggest?
johnep

We had a CPD evening on Benefit/Risk assessment and relaying that to the patient without scaring the shit out of them.

We had a talk by a Rheumatologist (My wife's rheumatologist actually) who firstly told us to always say Benefit/Risk rather than Risk/Benefit but that's just an aside.

When asked about Methotrexate interactions he said that he believed that at doses for Arthritis etc. MTX held no serious interaction problems.

It was only when you got up to serious Cytotoxic doses for cancer etc., which you're unlikely to see in community anyway, that the interactions became a real problem.

I'm always wary of MTX interactions but after hearing that I lose a lot less sleep over them.