Quote:
Originally Posted by richtagg  Hi there,
It depends on the drug. As a rule of thumb it is safe to say that there is a difference between the amount of drug needed to obtain therapeutic concentrations depending on the route you administer the drug.
A drug administered orally will need to enter the system via absorption through the Gastro-intestinal system whereas a drug administered via an inhaler will need to be absorbed through the lungs. These are very different environments so there are differences in the amount of drug absorbed.
If you consider the example of Salbutamol, a drug used in asthma to relax the muscles in the lungs, you need to give more of the drug if you give tablets rather than inhalers.
Does this answer your question? |
yeah it does - cheers!
so am i right in thinking that because the drug e.g. Salbutamol goes through the Gastro-intestinal system, there's more chance that some of it will not be absorbed (and therefore excreted) hence why a larger dose is required than if inhaling Salbutamol cos its going more or less directly into the blood stream via the lungs (no digestion and more drug absorbtion taking place)?