Quote:
Originally Posted by johnep  MSD produced indocid in a coated tablet with a minute hole produced by laser. However, high local concentration if hole against stomach wall caused severe problems and product was dropped.
johnep |
I remember that - it was called Osmosin.
There might be two things at work with the NSAIDs, the direct effect and the systemic effect. The direct effect might be caused by a 'lump' of the drug being in one place in the stomach acting on the mucosa, whereas the systemic effect involves more even drug distribution. A lot of them are propionic acid derivatives, so the high pH of the stomach would make them less dissociated and relatively more able to pass through the stomach wall. Or something like that science stuff kind of thing...I suppose, maybe possibly.