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Originally Posted by mm45  yeah I relise the fact that NSAIDs inhibit PG synthesis and mucous secretion etc. But if e/c are no more benefitical then normal NSAID why are so many doctors prescribing them, surely it could save the nhs money if they just stuck to the normal coating... |
I have always thought that these drugs also have a local irritant effect on the stomach, as well as the systemic effect. As well as enteric coating tablets, this can also be reduced by using the drug in another forrm - e.g. Diclofenac suppositories. I'm sure there must be studies to show that using e/c tabs, suppositories or even injections have less GI side effects then plain oral tablets.