 SSRIs
Fluoxetin specially when starts make significant restlessness compared with other SSRIs. so it`s not rationally to use them at night . but other SSRIs such Citalopram & Serteralin have paradoxical effect.(almost they make people fall to sleep) in some people they induce anxiety-restless(first weeks of treatment) and in some somnolence.
then when i give patients SSRIs notice them use at start of day BUT if they feel somnolence take drug before bed.
it was always a question for me.why some people react to drug differentially?! their liver enzyms? their genetics? their CNS??
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