Pari
If injected intra-muscularly saline can cause muscle pain. See : -
http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Citation
If given IV saline can cause: -
thirst, interdialytic weight gain, hypertension
It can also be used to treat cerebral oedema because it has an osmotic effect on the brain because of its high tonicity, and ability to effectively remain outside the blood-brain barrier.
Of course isotonic saline is used to keep blood volume maintenance in those who require intravenous fluid, such as trauma patients.
Do you need a more detailed answer?