Quote:
Originally Posted by lmcder  Are there other drugs, which like carbamazepine are autoinducers?
Im nearing the end of my pre reg year and only found out about this property of carbamazepine YESTERDAY!! Please educate me!!!!!
Regards, L X |
I remember hearing about this in Uni pharmacology/kinetics lectures. Here's the relevant bits cut and pasted from my old notes.
• Drugs that stimulate hepatic microsomal enzyme production may stimulate their own metabolism
• This process is known as ‘self-induction’ or ‘auto-induction’
• In some cases, this process explains the phenomenon of tolerance
• Examples of drugs that induce their own hepatic metabolism include:
o Carbamazepine (Anticonvulsant)
o Diazepam (Benzodiazepine)
o Glutethimide (Hypnotic sedative)
o Glyceryl trinitrate (Vasodilator)
o Meprobamate (Anxiolytic)
o Phenobarbital (Barbiturate)
o Phenylbutazone (NSAID)
o Phenytoin (Antiepileptic)
o Tolbutamide (Sulphonylurea)