I try to expect the blood level of this drug by using the following formulas:
IV Cmax in the steady condition=
IVGTT Cmax in the steady condition=
Cmin in the steady condition=
As above it is said that peak serum levels of 69-90 ug/ml are achieved followinga 1gm dose of ceftazidime(IV). Organisms with an MIC<=8 ug/ml are considered sensitive.
So accroding to the formluas I can expect the Cmax and the Cmin in different regimens.The resault is as follow:
All regimens T=0.5h Half-life of Ceftazidime is 2h.
Dose Fequency Cmax(ug/ml) Cmin(ug/ml)
1 gm IVGTT Q6H 72.4 - 94.4 10.8 - 14.0
2 gm IVGTT Q12H 64.4 - 83.9 1.2 - 1.6
So I think for Serve infection the regimen of 1 gm Q6H can make sure the serum level of Ceftazidime all upper the MIC while 2 gm Q12H can not.
Any ideas? Am I right?